Mechanisms of sustained high firing rates in two classes of vestibular nucleus 2 neurons : differential contributions of resurgent Na , Kv 3 , and BK currents 3 4 5
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چکیده
1 Mechanisms of sustained high firing rates in two classes of vestibular nucleus 2 neurons: differential contributions of resurgent Na, Kv3, and BK currents 3 4 5 Aryn H. Gittis, Setareh H. Moghadam, Sascha du Lac 6 7 8 Systems Neurobiology Laboratory 9 Howard Hughes Medical Institute 10 Salk Institute for Biological Studies 11 10010 North Torrey Pines Road 12 La Jolla, CA 92037 13 14 15 16 Articles in PresS. J Neurophysiol (June 30, 2010). doi:10.1152/jn.00378.2010
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Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.
To fire at high rates, neurons express ionic currents that work together to minimize refractory periods by ensuring that sodium channels are available for activation shortly after each action potential. Vestibular nucleus neurons operate around high baseline firing rates and encode information with bidirectional modulation of firing rates up to several hundred Hz. To determine the mechanisms th...
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Sodium currents in fast firing neurons are tuned to support sustained firing rates >50-60 Hz. This is typically accomplished with fast channel kinetics and the ability to minimize the accumulation of Na channels into inactivated states. Neurons in the medial vestibular nuclei (MVN) can fire at exceptionally high rates, but their Na currents have never been characterized. In this study, Na curre...
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Sodium currents in fast firing neurons are tuned to support sustained firing rates > 50-60 Hz. This is typically accomplished with fast channel kinetics and the ability to minimize the accumulation of Na channels into inactivated states. Neurons in the medial vestibular nuclei (MVN) can fire at exceptionally high rates, but their Na currents have never been characterized. In this study, Na curr...
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